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its much more than just a gut all starts there!

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Inflammatory bowel diseases (IBD) include Crohn’s Disease, Ulcerative colitis, Microscopic Colitis

The exact cause of inflammatory bowel disease remains unknown.  What is known is that it starts with inflammation
lets use the tools we have to reduce inflammation in the body! Studies suggest Incorporating Exceptionally High Phenolic EVOO may help

Gastrointestinal diseases 

include functional and structural diseases include peptic ulcer disease, gastritis, gastroenteritis, irritable bowel syndrome (IBS), Diverticular Disease, Colon Polyps, celiac disease, Crohn's disease, gallstones, fecal incontinence, lactose intolerance, Hirschsprung disease, abdominal adhesions, Barrett's esophagus, appendicitis, indigestion (dyspepsia), intestinal pseudo-obstruction, pancreatitis, short bowel syndrome, Whipple’s disease, Zollinger-Ellison syndrome, malabsorption syndromes and hepatitis
Did you know many intestinal disease can be prevented or minimized by maintaining a healthy lifestyle, practicing good bowel habits and getting screened for cancer.  Let's see what the studies say. about EVOO

Studies suggest the following:

  • Hydroxytyrosol Dextran Sulfate Sodium-Induced Colitis

  • Hydroxytyrosol modulates  the oxidative and inflammatory process in  gastrointestinal pathologies

  • Management of abdominal pain, a common symptom of IBDs and IBS

  • need for dietary approaches and functional foods that could modulate the course of IBD

  • shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds

  • Potential of  bioactive EVOO phenolic S-(-)-oleocanthal as a nutraceutical

  • manipulating the gut microbiota in metabolic syndrome and obesity-related disease, liver disease, IBD and colorectal cancer

  • PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells

  • Oleuropein protects the hypothalamus from oxidative stress by improving mitochondrial function through activation of the Nrf2-mediated signaling pathway

  • IBD, comprising of Crohn’s disease, ulcerative colitis, and an unclassified type of IBD are characterized by chronic and recurring inflammation of the intestinal mucosa.  EVOO’s (poly)phenols  such as Hydroxytyrosol its acetate (HT-Ac) improved experimental colitis  via reducing upregulation of both pro-inflammatory enzymes COX-2 and iNOS

  • EVOO’s (poly)phenols  such as Hydroxytyrosol and its acetate (HT-Ac) inhibited the NF-κB signaling pathway in addition to JNK MAPK phosphorylation

  • Confirmed significant anti-inflammatory and immunomodulatory effects of dietary EVOO and its bioactive components supplementation in preclinical models of autoimmune diseases, such as inflammatory bowel disease

  • EVOO possess anti-inflammatory, antiproliferative and antiapoptotic effects that protective/preventive in the Ulcerative Colitis-associated Colorectal Cancer. This beneficial effect was correlated with a better disease activity index, a minor number of dysplastic lesions, a lower β-catenin immunoreactivity, a proinflammatory cytokine levels reduction, a non modification of p53 expression and, COX-2 and iNOS reduction in the colonic tissue

  • Hydroxytyrosol (HT), preserved intestinal barrier integrity, as shown by the diamine oxidase (DAO) serum levels and tight junction (zonula occludens (ZO) and occludin) expression in pancreas and colon. Our findings demonstrated that HT would be an important therapeutic tool against pancreatitis-induced injuries in the pancreas and gut

  • Non-Celiac Gluten Sensitivity and Protective Role of Dietary Polyphenols effects of polyphenols as a dietary strategies to counteract the toxic effects of gluten, potentially resulting in the improved quality of life of patients with gluten-related disorders.  Polyphenols can exhibit a direct action of capturing gluten, the main trigger of gluten-related diseases, thereby reducing its bioavailability and associated toxic effects. Polyphenols can also dampen the toxic effects of gluten, both at the intestinal and systemic levels, by reducing oxidative stress and inflammation, by regulating the immune response, and by improving the health of the intestinal microbiota and the function of the intestinal barrier

  • Hydroxytyrosol activates stem cells in HPC; decreases marker of aging (Iba1 and lipofuscin)

  • Hydroxytyrosol potential strategy for pancreatitis and intestinal comorbidity treatment because it reducing inflammatory cell infiltration, cytokine overexpression, oxidative stress and the NRF2 pathway, counteracted pancreatic damage and associated intestinal injury during pancreatitis

  • Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

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