​Studies suggest the following:

​

• targets hematopoietic tumor cell lines and triggers at least two cell death mechanisms

• induced cell death in all cancer cells examined as rapidly as 30 minutes after treatment in the absence of serum. OC treatment of non-transformed cells suppressed their proliferation but did not cause cell death. OC induced both primary necrotic and apoptotic cell death via induction of lysosomal membrane permeabilization (LMP)

• damage to cancer cells' lysosomes leading to cellular toxicity in vitro and in vivo

• omega-9 pharmacological activities in context of inflammation management for its different natural forms in different dietary sources suppression of migration and proliferation of breast cancer cells, as well stimulation of tumor suppressor genes

• oleuropein is a potent inhibitor of human epidermal growth factor receptor 2, a protein that is frequently overexpressed in breast cancer cells

• significant reduction of inflammation detected after omega-9 can further contribute to the beneficial properties facilitated by unsaturated fatty acid-enriched diets.

• Oleocanthal was reported to suppress melanoma, breast, liver, and colon cancer cells by inhibition of proliferation, cell-cycle arrest, induction of apoptosis, or decrease in several processes, such as migration, immune evasion, angiogenesis and inflammation.  Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks

• Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins

• lower risk of cancer mortality in the general population, and all-cause mortality among cancer survivors as well as colorectal, head and neck, respiratory, gastric, liver and bladder cancer risks

• lower skin cancer risk in women, particularly melanoma and BCC

• reduce overall cancer risk

• protective effect of EVOO may account for its minor compounds and its ratio of n-3/n-6PUFAs (higher than the ratios found in many seed oils)

• antitumor effects

• induce anti-cancer effects by suppressing the expression of the lipogenic enzyme FASN in HER2-overexpressing breast carcinoma cells

• stereochemistryplatform for the design of new HER2-targeting agents

• antiproliferative cytostatic

• biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

• Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2 

• EVOO extracts in the prevention and treatment of non-melanoma skin cancers

• EVOO inhibits cell proliferation and induces apoptotic death as revealed by sub-G1 cell cycle analyses and Annexin-V staining in all lineages analyzed except lung carcinoma cell lines.

• EVOO is a COX inhibitor and low long term of COX inhibitors have significant benefits as prevention from developing rectum and breast cancer

• chemotherapeutic potential of EVOO on human liver and colon cancer cells through ROS generation cancer

• Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer

• Oleacein, EVOO secoiridoid, elicits significant anti-tumor activity by promoting cell cycle arrest and apoptosis. Data highlight an epigenetic impact of Oleacein in Multiple Myeloma, as demonstrated by the impairment of the MM acetylome, likely via Sp1-dependent transcriptional inhibition of HDACs

• Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells

• Optimization of Taste-Masked (–)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities

• 4152 women aged 60–80 years of age on a high phenolic EVOO Mediterranean Diet experienced a 62% significant reduction (HR: 0.38, 95% CI: 0.16–0.87) in the risk of breast cancer compared to women in the control group 

• hydroxytyrosol (HT), some papers reported chemoprevention via prevention of DNA damage in PBMC and inhibition of breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell proliferation

• Olive oil phenols (OOPs) are associated with the prevention of many human cancers.  Important information was generated, encouraging further in vivo investigations of the OOPs presenting strong bioactivity in several cancer cell lines. Moreover, the important antiproliferative cytostatic effect of oleuropein and ligstroside aglycones ((3a,b) and (4a,b)) in the H1437 lung cancer and Caco-2 colon carcinoma cells, stronger than that of oleocanthal (1), which has been the most effective and well-studied OOP until now, highlights the selectivity in the action of the different OOPs on different cancer types

• Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

• Oleuropein acts as an anticancer agent by several major mechanisms, including targeting HER2, epigenetic modifications, interfering with MAPK pathway, modulation of apoptosis and PI3K/AKT signalling axis as well as by reducing ROS production in different cell types.

• Olive oil's bitter principle (i.e., oleuropein aglycone) is among the first examples of how selected nutrients from an EVOO-rich "Mediterranean diet" directly regulate HER2-driven breast cancer disease

• Oleuropein strongly induces apoptotic cell death in HeLa human cervical carcinoma cells

• results demonstrate that Oleuropein inhibit in vitro thyroid cancer cell proliferation acting on growth-promoting signal pathways, as well as exerting antioxidant effects. 

• targets hematopoietic tumor cell lines and triggers at least two cell death mechanisms

• induced cell death in all cancer cells examined as rapidly as 30 minutes after treatment in the absence of serum. OC treatment of non-transformed cells suppressed their proliferation but did not cause cell death. OC induced both primary necrotic and apoptotic cell death via induction of lysosomal membrane permeabilization (LMP)

• damage to cancer cells' lysosomes leading to cellular toxicity in vitro and in vivo

• omega-9 pharmacological activities in context of inflammation management for its different natural forms in different dietary sources suppression of migration and proliferation of breast cancer cells, as well stimulation of tumor suppressor genes

• oleuropein is a potent inhibitor of human epidermal growth factor receptor 2, a protein that is frequently overexpressed in breast cancer cells

• significant reduction of inflammation detected after omega-9 can further contribute to the beneficial properties facilitated by unsaturated fatty acid-enriched diets.

• Oleocanthal was reported to suppress melanoma, breast, liver, and colon cancer cells by inhibition of proliferation, cell-cycle arrest, induction of apoptosis, or decrease in several processes, such as migration, immune evasion, angiogenesis and inflammation.  Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks

• Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins

• lower risk of cancer mortality in the general population, and all-cause mortality among cancer survivors as well as colorectal, head and neck, respiratory, gastric, liver and bladder cancer risks

• lower skin cancer risk in women, particularly melanoma and BCC

• reduce overall cancer risk

• protective effect of EVOO may account for its minor compounds and its ratio of n-3/n-6PUFAs (higher than the ratios found in many seed oils)

• antitumor effects

• induce anti-cancer effects by suppressing the expression of the lipogenic enzyme FASN in HER2-overexpressing breast carcinoma cells

• stereochemistryplatform for the design of new HER2-targeting agents

• antiproliferative cytostatic

• biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

• Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2 

• EVOO extracts in the prevention and treatment of non-melanoma skin cancers

• EVOO inhibits cell proliferation and induces apoptotic death as revealed by sub-G1 cell cycle analyses and Annexin-V staining in all lineages analyzed except lung carcinoma cell lines.

• EVOO is a COX inhibitor and low long term of COX inhibitors have significant benefits as prevention from developing rectum and breast cancer

• chemotherapeutic potential of EVOO on human liver and colon cancer cells through ROS generation cancer

• Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer

• Oleacein, EVOO secoiridoid, elicits significant anti-tumor activity by promoting cell cycle arrest and apoptosis. Data highlight an epigenetic impact of Oleacein in Multiple Myeloma, as demonstrated by the impairment of the MM acetylome, likely via Sp1-dependent transcriptional inhibition of HDACs

• Oleil Hydroxytyrosol (HTOL) Exerts Anti-Myeloma Activity by Antagonizing Key Survival Pathways in Malignant Plasma Cells

• Optimization of Taste-Masked (–)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities

• 4152 women aged 60–80 years of age on a high phenolic EVOO Mediterranean Diet experienced a 62% significant reduction (HR: 0.38, 95% CI: 0.16–0.87) in the risk of breast cancer compared to women in the control group 

• hydroxytyrosol (HT), some papers reported chemoprevention via prevention of DNA damage in PBMC and inhibition of breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell proliferation

• Olive oil phenols (OOPs) are associated with the prevention of many human cancers.  Important information was generated, encouraging further in vivo investigations of the OOPs presenting strong bioactivity in several cancer cell lines. Moreover, the important antiproliferative cytostatic effect of oleuropein and ligstroside aglycones ((3a,b) and (4a,b)) in the H1437 lung cancer and Caco-2 colon carcinoma cells, stronger than that of oleocanthal (1), which has been the most effective and well-studied OOP until now, highlights the selectivity in the action of the different OOPs on different cancer types

• Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

• Oleuropein acts as an anticancer agent by several major mechanisms, including targeting HER2, epigenetic modifications, interfering with MAPK pathway, modulation of apoptosis and PI3K/AKT signalling axis as well as by reducing ROS production in different cell types.

• Olive oil's bitter principle (i.e., oleuropein aglycone) is among the first examples of how selected nutrients from an EVOO-rich "Mediterranean diet" directly regulate HER2-driven breast cancer disease

• Oleuropein strongly induces apoptotic cell death in HeLa human cervical carcinoma cells

• results demonstrate that Oleuropein inhibit in vitro thyroid cancer cell proliferation acting on growth-promoting signal pathways, as well as exerting antioxidant effects.