Cardiovascular Studies 

Studies suggest the following:

• EVOO has anti-atherosclerotic potential, favouring endothelial function and preserving blood pressure, maintaining lipoprotein functionality, exerting anti-inflammatory and antioxidant effects, and modulating gene expression in several tissues to maintain proper homeostasis.

• Counteraction of LDL oxidations

• EVOO is a COX inhibitor and low long term of COX inhibitors have significant benefits as prevention from developing cardiovascular disease

• polyphenolic components  interfere with biochemical events that are implicated in atherogenetic disease, thus proposing a new link EVOO and prevention of Coronary Heart Disease 

• hydroxytyrosol is capable to counteract oxidative stress, inflammation, vascular aging, and arterial stiffness; thus, it is beneficial to preserve endothelial function 

• olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers

• protect against coronary heart disease by  reducing cholesterol absorption, which decreases delivery of cholesterol to the liver

• Inhibition of eicosanoids correlated to EVOO total phenolic content

• Mitochondrial impairment increases with age leading to dysregulation of molecular.  EVOO therapies involved in the alteration of cellular energetics with aging and injury with a neurobiological perspective

• hydroxytyrosol inhibited platelet aggregation and that a decrease in thromboxane synthesis along with an increase in nitric oxide production

• results are promising showing that EVOO can exert antiplatelet actions in real, acute or long-term, trials and at least part of this antiplatelet action can be attributed to the phenolic content of EVOO

• Hydroxytyrosol (HT) has been studied expansively over the decades for its anti-inflammatory, anti-thrombotic, anti-atherogenic, hypoglycemic effects, and neuro-regeneration  

• Counteraction of LDL oxidations

• Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial Function

• minimum intake of two tablespoons (25 ml) a day could significantly decrease systolic blood pressure in as little as three weeks

• polyphenols (OP) combating various CVD 

• improves blood pressure, cholesterol level, and thrombogenesis

• Inhibition of eicosanoids correlated to EVOO total phenolic content

• Oleuropein is best known for its blood pressure-lowering effect.  Oleuropein significantly reduces systolic and diastolic blood pressure

• polyphenols increase the HDL level, prevent from oxidative stress, reduce thrombogenic, endothelial dysfunction, BP, and inflammation, and alter gene expression responsible for atherosclerosis process

• evidence on olive oil vasculoprotective effects is abundant, which scientifically enables recommending its consumption as the major type of dietary fat. Pharmacological activities at the molecular level of olive oil compounds can be used as potential preventive and/or anti-atherosclerotic therapeutic targets

• Hydroxytyrosol positively regulates the anti-oxidant defense system in endothelial cells and provides a molecular basis for the prevention of cardiovascular diseases by Hydroxytyrosol

• tyrosol, hydroxytyrosol, oleuropein and oleocanthal have been reported to reduce several risk factors of CVD and cancer such as diabetes mellitus, hypertension, dyslipidemia and obesity

• specific phenolic content within EVOO can influence platelet aggregation responses in healthy male adults.

• hydroxytyrosol is capable to counteract oxidative stress, inflammation, vascular aging, and arterial stiffness; thus, it is beneficial to preserve endothelial function both in vitro and in vivo

• hydroxytyrosol endothelial dysfunction and pathological angiogenesis by ameliorating mitochondrial function, thus suggesting hydroxytyrosol as a potential mitochondria-targeting antioxidant in the inflamed endothelium

• Physiological Hydroxytyrosol metabolites, synthesized by using an intestinal cell model, for the protection against endothelial dysfunction.

• EVOO consumption is associated with reduced risks of cardiovascular disease and mortality in individuals at high cardiovascular risk

• using phenolic compounds encapsulated in synergistic nanoparticles is likely to enhance our ability to prevent and treat a variety of anti-inflammatory diseases, cancer, rheumatoid arthritis, allergic diseases, cardiovascular disease, and neurogenerative disease